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We are determining whether, and to what extent, biomechanical, biochemical, and topographical signals can modulate phenotypic characteristics of chondrocytes from different anatomic locations. Our long-term objective is to tissue engineer functional articular cartilage using non-articular chondrocytes.
We are investigating biomechanical signals present during early embryonic development. Our long-term objective is to elucidate principles of mechanical regulation during embryonic development and use those principles to develop biomimetic tissue engineering approaches, that is tissue engineering approaches that emulate some aspects of normal tissue development.
We are measuring, simulating, and modulating tissue differentiation in vivo to identify mechanical stimuli that are regulators of progenitor cell differentiation. Our goal is to broadly facilitate continued progress in the field of tissue engineering.
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