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Our goal is to understand how biophysical stimuli (e.g., stresses and strains) regulate tissue development, maintenance, and disease progression and to use that understanding to develop biomimetic bench-top research platforms, biomedical devices, and tissue-engineering and regenerative medicine approaches. Current projects focus on the treatment of orthopaedic injuries and on cancer.
Our goal is to integrate innovative computational (for example, cell tracking) and experimental (for example, cell imaging) approaches to enable the study of cells in increasingly advanced and physiologically relevant in vitro environments. Current projects focus on dense cells interacting with 2D or 3D shape-changing biomaterial substrates and scaffolds.
We are determining whether, and to what extent, biomechanical, biochemical, and topographical signals can modulate phenotypic characteristics of chondrocytes. Our long-term objective is to contribute key understanding to the engineering of functional articular cartilage. Current projects focus on the effects of mechanobiological signals from smart materials and on hypoxic expansion of the preparation and biomechanical properties of engineering cartilage.
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